Brighton, who have 10 points from their first 10 matches, have a few injury concerns ahead of this south coast showdown.
Former Saint Adam Lallana looks set to miss out as he continues to recover from a groin problem. Lallana lasted just eight minutes against Liverpool as he came on as a second half substitute for Aaron Connolly but soon disappeared back down the tunnel.
Neal Maupay is hoping to be fit after tweaking a hamstring shortly after missing a penalty against Liverpool last week, while Tariq Lamptey is available for selection once more after his one match ban
Scroll down and click through to see how Graham Potter's men may line-up against eighth placed Southampton.
Neal Maupay is hoping to be fit after tweaking a hamstring shortly after missing a penalty against Liverpool last week, while Tariq Lamptey is available for selection once more after his one match ban