Brighton, who have 10 points from their first 10 matches, have a few injury concerns ahead of this south coast showdown.
Former Saint Adam Lallana looks set to miss out as he continues to recover from a groin problem. Lallana lasted just eight minutes against Liverpool as he came on as a second half substitute for Aaron Connolly but soon disappeared back down the tunnel.
Neal Maupay is hoping to be fit after tweaking a hamstring shortly after missing a penalty against Liverpool last week, while Tariq Lamptey is available for selection once more after his one match ban
Scroll down and click through to see how Graham Potter's men may line-up against eighth placed Southampton.
5. Tariq Lamptey
Available once again after a one match ban against Liverpool. Been excellent for Albion this season and I expect to go straight back into the tonight. Tough on Veltman though who did well last Saturday
6. Yves Bissouma
The Mali international has been the main man in the Albion midfield this campaign. Lots of speculation surrounding a January switch to Arsenal but Brighton will need their competitive midfielder at his best against a physical and powerful Saints team
7. Pascal Gross
Scored a late penalty against Liverpool to earn a draw and expected to keep his place. A very underrated figure in this Albion team. Covers plenty of ground and always likely to pop up with an assist or a goal
8. Leo Trossard
Expected to start as Adam Lallana continues to struggle with a groin issue. Trossard is back to fitness after a hip problem. He can offer that vital link between midfield and attack