Brighton, who have 10 points from their first 10 matches, have a few injury concerns ahead of this south coast showdown.
Former Saint Adam Lallana looks set to miss out as he continues to recover from a groin problem. Lallana lasted just eight minutes against Liverpool as he came on as a second half substitute for Aaron Connolly but soon disappeared back down the tunnel.
Neal Maupay is hoping to be fit after tweaking a hamstring shortly after missing a penalty against Liverpool last week, while Tariq Lamptey is available for selection once more after his one match ban
Scroll down and click through to see how Graham Potter's men may line-up against eighth placed Southampton.
9. Solly March
Enjoying his best season for Brighton at left wing back. Provides width and is a real threat with crosses and has two goals to his name this season.
10. Aaron Connolly
Played an intense and eventful hour against Liverpool last week. Won a penalty missed a sitter and caused Liverpool all sorts of problems. Could start up top with Danny Welbeck as Neal Maupay is struggling with a hamstring issue
11. Danny Welbeck
Offers Brighton a focal point to their attack. Scored a cracker against Villa and also played well against Liverpool and won the last gasp penalty that Gross converted. Will be confident heading into the Saints match