The Hammers have failed to beat Brighton in the Premier League, losing three and drawing three of their six previous meetings with the Seagulls in the top flight.
Brighton have also performed better on their travels this season, picking up eight of their 12 points away from the Amex.
Graham Potter' s men will however be without their impressive young wing back Tariq Lamptey who is struggling with a hamstring issue.
Potter may also recall Danny Welbeck to the starting XI after his late leveller from the bench against Sheffield United last time out.
Scroll down and click through to see how Albion could line-up..
5. Joel Veltman
The versatile Dutchman will likely fill the right wing back slot as Tariq Lamptey continues to struggle with a hamstring issue
6. Adam Lallana
The 32-year-old will likely play a central midfield role alongside Yves Bissouma
7. Yves Bissouma
Adds energy and drive to the Albion midfield. Continues to be linked with Arsenal and Liverpool
8. Leo Trossard
Linking midfield attack, Trossard will likely feature as the most advanced of the midfield three