The Hammers have failed to beat Brighton in the Premier League, losing three and drawing three of their six previous meetings with the Seagulls in the top flight.
Brighton have also performed better on their travels this season, picking up eight of their 12 points away from the Amex.
Graham Potter' s men will however be without their impressive young wing back Tariq Lamptey who is struggling with a hamstring issue.
Potter may also recall Danny Welbeck to the starting XI after his late leveller from the bench against Sheffield United last time out.
Scroll down and click through to see how Albion could line-up..
9. Solly March
Continues to impress this season at left wing back
10. Danny Welbeck
Scored the leveller against Sheffield United after coming on as a second half sub. Will likely feature from the start at the London Stadium and lead Albion's attack
11. Neal Maupay
The Frenchman has not been at his best this season. It will be a close call between Aaron Connolly and Maupay for this one.