The Italian has left Spurs by mutual consent after 16 months in charge.
His assistant Cristian Stellini has been named as interim head coach for the rest of the campaign.
The 53-year-old branded his players ‘selfish’, and savaged the club’s culture, in the wake of Tottenham’s 3-3 draw at relegation-threatened Southampton in their last league game before the international break.
The north London club are fourth in the Premier League, but have been knocked out of all cup competitions.
In a statement posted on Tottenham’s website, chairman Daniel Levy said: “We have ten Premier League games remaining and we have a fight on our hands for a Champions League place. We all need to pull together. Everyone has to step up to ensure the highest possible finish for our club and amazing, loyal supporters.”
Here’s who could be the next man in charge at the Tottenham Hotspur Stadium, courtesy of Paddy Power.
5. Luis Enrique - 9/1
Luis Enrique enjoyed unprecedent success at the helm of FC Barcelona between 2014 and 2017. Barça won two La Ligas, three Copa del Reys, and the Supercopa de España, UEFA Champions League, UEFA Super Cup and FIFA Club World Cup under the 52-year-old's stewardship. Enrique was then named Spain manager in 2018. He led Spain to the semi-finals of UEFA Euro 2020 but was ousted following a shock penalty shootout defeat to Morocco in the round of 16 of the 2022 FIFA World Cup Photo: Julian Finney/Getty Images
6. Zinedine Zidane - 11/1
One of the greatest players of all time has quickly become one of the greatest managers of the modern era. Zinedine Zidane enjoyed a glittering playing career - winning the FIFA World Cup, UEFA European Championship and UEFA Champions League - but his managerial career is just as impressive. The France legend won two La Ligas and two Supercopa de Españas during two spells at Real Madrid. But those achievements were dwarfed by three back-to-back UEFA Champions League titles, and two consecutive FIFA Club World Cups and UEFA Super Cups as Los Merengues reclaimed their crown as kings of European football under Zidane Photo: DANIEL LEAL/AFP via Getty Images
7. Thomas Frank - 12/1
Thomas Frank has won acclaim for his excellent work at Brentford. The Dane guided the Bees to the Premier League promised land, via the play-offs, in 2020/21. Brentford finished 13th in their first season back in the top-flight. The west London club sit eighth this campaign, but are just seven points off the UEFA Champions League qualifying places Photo: Clive Rose/Getty Images
8. Roberto De Zerbi - 14/1
Roberto De Zerbi has won plaudits for his supreme work at Brighton & Hove Albion since succeeding predecessor Graham Potter in September. The Italian has taken seventh-placed Albion to within seven points of UEFA Champions League football next season, as well as the semi-finals of the FA Cup. The 43-year-old also lifted the 2021 Ukrainian Super Cup during his short stay at Shakhtar Donetsk Photo: Naomi Baker/Getty Images