The flying full-back was due to play in Friday’s 2023 UEFA European Under-21 Championship Group G qualification match with Andorra at AFC Bournemouth’s Dean Court but has returned home due to illness.
The 21-year-old, who was due to make his first England appearance in 18 months after a series of injury setbacks, will also miss the Young Lions’ trip to Albania on Tuesday evening.
No replacement has been called up by England under-21s manager Lee Carsley.
Brighton will hope Lamptey will have recovered by the time of their home Premier League encounter with relegation-threatened Norwich City on Saturday, April 2.
The Seagulls will still have representation in the Young Lions’ squad despite Lamptey’s withdrawal.
Goalkeeper Carl Rushworth, who is on a season-long loan at Walsall, could be in line to win his first England cap at under-21 level.
Check out the latest Premier League speculation below...
1. Villa plot De Vrij swoop
Aston Villa are keeping tabs on Inter Milan defender Stefan de Vrij ahead of a potential £40m move. (Football Insider) | Getty Images
2. Kamara in demand
Tottenham have joined the race to sign Marseille maestro Boubacar Kamara, with Newcastle and West Ham also keen. (Goal) | Getty Images
3. Man United in for Osimhen
Manchester United are the frontrunners to sign Napoli forward Victor Osimhen. (Tuttosport) | Getty Images
4. LEEDS, ENGLAND - MARCH 13: Jesse Marsch, Manager of Leeds United, celebrates their side's win after the final whistle of the Premier League match between Leeds United and Norwich City at Elland Road on March 13, 2022 in Leeds, England. (Photo by George Wood/Getty Images)
Leeds United have reportedly joined the race to land Rangers prodigy Rory Wilson. Liverpool, Manchester United, Manchester City and Newcastle are also in pursuit. (Daily Star) | Getty Images