The flying full-back was due to play in Friday’s 2023 UEFA European Under-21 Championship Group G qualification match with Andorra at AFC Bournemouth’s Dean Court but has returned home due to illness.
The 21-year-old, who was due to make his first England appearance in 18 months after a series of injury setbacks, will also miss the Young Lions’ trip to Albania on Tuesday evening.
No replacement has been called up by England under-21s manager Lee Carsley.
Brighton will hope Lamptey will have recovered by the time of their home Premier League encounter with relegation-threatened Norwich City on Saturday, April 2.
The Seagulls will still have representation in the Young Lions’ squad despite Lamptey’s withdrawal.
Goalkeeper Carl Rushworth, who is on a season-long loan at Walsall, could be in line to win his first England cap at under-21 level.
Check out the latest Premier League speculation below...
5. Toon want Leno
Arsenal want £10-£15 million for Bernd Leno amid interest from Eddie Howe’s Newcastle United. (Goal) | Arsenal FC via Getty Images
6. Ings exit would be a ‘surprise’
Aston Villa striker Danny Ings’ potential summer exit for Brighton ‘would come as a surprise’ less than 12 months after his arrival at Villa Park. (Pete O’Rourke) | Getty Images
7. Fulham eye Pope
Fulham want to make England goalkeeper Nick Pope their number one in the Premier League next season. (The Sun) | Getty Images
8. Magpies leading Botman race
Newcastle United are in pole position to sign Sven Botman from Lille for around £30million this summer even though he has agreed personal terms with AC Milan. (Football Insider) | Getty Images