The Hammers are firmly in the hunt for European football, lying in sixth place in the Premier League ahead of their trip to the south coast.
Declan Rice could return for West Ham after six weeks out with a knee injury. Aaron Cresswell should also be fit despite limping off in last weekend’s defeat by Everton.
But Mark Noble, Arthur Masuaku and Manuel Lanzini are injury doubts.
Former Brighton loanee Jesse Lingard also looks set to play a key role for West Ham once more.
Scroll down and click through to see how West Ham could line-up against the Seagulls.
1. Łukasz Fabianski
The 36-year-old Poland goalkeeper continues to perform at a high level in the Premier League
2. Vladimir Coufal
West Ham's Czech signings have been a key reason behind West Ham's push for Europe
3. Craig Dawson
Proved to an inspired signing for West Ham. Very consistent at the heart of the defence